A 4-Week Repeated Oral Dose Toxicity Study of Ssanghwa-Tang in Crl:CD Sprague Dawley Rats
Table 7
Relative organ weight (%) of rats treated with SHT for 4 weeks.
Dose (mg/kg/day)
0
1000
2000
5000
Male
Body weight
393.7 ± 24.60
394.2 ± 29.80
400.3 ± 31.07
393.5 ± 30.70
Brain
0.514 ± 0.0131
0.536 ± 0.0509
0.502 ± 0.0514
0.521 ± 0.0582
Heart
0.350 ± 0.0390
0.363 ± 0.0150
0.355 ± 0.0478
0.345 ± 0.0312
Lung
0.398 ± 0.0320
0.384 ± 0.0168
0.394 ± 0.0300
0.395 ± 0.0297
Kidneys
0.839 ± 0.0346
0.914 ± 0.0379
0.898 ± 0.0603
0.936 ± 0.0673
Liver
3.295 ± 0.1160
3.331 ± 0.2191
3.427 ± 0.2521
3.740++ ± 0.1483
spleen
0.192 ± 0.0371
0.207 ± 0.0251
0.189 ± 0.0277
0.238 ± 0.0566
Testes
0.860 ± 0.0642
0.798 ± 0.0494
0.823 ± 0.0751
0.860 ± 0.0670
Prostate
0.135 ± 0.0316
0.123 ± 0.0290
0.100 ± 0.0235
0.122 ± 0.0142
Epididymis
0.273 ± 0.0298
0.263 ± 0.0201
0.260 ± 0.0284
0.304 ± 0.0584
Thymus
0.127 ± 0.0132
0.114 ± 0.0215
0.158 ± 0.0316
0.147 ± 0.0152
THPA
0.005 ± 0.0006
0.006 ± 0.0010
0.006 ± 0.0010
0.006 ± 0.0015
PITG
0.003 ± 0.0002
0.003 ± 0.0002
0.003 ± 0.0003
0.003 ± 0.0002
ADRG
0.016 ± 0.0029
0.017 ± 0.0032
0.015 ± 0.0027
0.014 ± 0.0006
SVCG
0.347 ± 0.0472
0.369 ± 0.0542
0.338 ± 0.0415
0.365 ± 0.0836
SALG
0.182 ± 0.0297
0.191 ± 0.0137
0.179 ± 0.0115
0.184 ± 0.0226
Female
Body weight
227.4 ± 14.60
227.1 ± 18.89
230.6 ± 17.99
217.6 ± 18.29
Brain
0.809 ± 0.0497
0.822 ± 0.0858
0.844 ± 0.0774
0.854 ± 0.0482
Heart
0.376 ± 0.0236
0.399 ± 0.0269
0.375 ± 0.0166
0.394 ± 0.0179
Lung
0.524 ± 0.0063
0.520 ± 0.0204
0.489 ± 0.0320
0.515 ± 0.0258
Kidneys
0.899 ± 0.0173
0.953 ± 0.0684
0.943 ± 0.0432
1.016+ ± 0.0595
Liver
3.534 ± 0.0908
3.584 ± 0.1903
3.698 ± 0.1469
3.914+ ± 0.1393
Spleen
0.236 ± 0.0322
0.244 ± 0.0228
0.237 ± 0.0211
0.299+ ± 0.0198
Ovaries
0.047 ± 0.0033
0.043 ± 0.0065
0.415 ± 0.0059
0.045 ± 0.0072
UTEC
0.255 ± 0.1209
0.210 ± 0.0159
0.243 ± 0.0596
0.248 ± 0.0500
Thymus
0.177 ± 0.0225
0.196 ± 0.0078
0.209 ± 0.0347
0.191 ± 0.0247
THPA
0.008 ± 0.0015
0.008 ± 0.0007
0.008 ± 0.0016
0.009 ± 0.0013
PITG
0.006 ± 0.0006
0.006 ± 0.0004
0.006 ± 0.0007
0.007 ± 0.0005
ADRG
0.034 ± 0.0054
0.031 ± 0.0034
0.033 ± 0.0065
0.035 ± 0.0049
SALG
0.206 ± 0.0156
0.200 ± 0.0149
0.194 ± 0.0121
0.202 ± 0.0225
Results are presented as mean ± SD. +Means Dunnett's LSD test significant at the 0.05 level. ++Means Dunnett's LSD test significant at the 0.01 level. THPA, thyroid and parathyroid glands; PITG, pituitary gland; ADRG, adrenal glands; SVCG, seminal vesicles with coagulating gland; SALG, salivary glands; UTEC, Uterus/cervix.
