Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 3 / Research Article
The Tissue Distribution of Four Major Coumarins after Oral Administration of Angelicae Pubescentis Radix Extract to Rats Using Ultra-High-Performance Liquid Chromatography Table 3 The concentrations of columbianetin, columbianetin acetate, osthole, and columbianadin in tissues (ng/mL)(n=6).
Tissues columbianetin columbianetin acetate osthole columbianadin 4h 6h 8h 4h 6h 8h 4h 6h 8h 4h 6h 8h Heart 735.0±316.5 814.6±192.3 86.9±80.2 77.4±41.2 175.0±50.0 45.3±40.7 183.5±56.0 227.4±39.3 135.5±28.6 0.00±0.00 54.3±36.8 0.0±0.0 Liver 1467.0±913.4 2032±514 325.4±262.5 183.3±22.2 1677.0±42.4 94.0±86.4 669.3±286.5 1352±529.0 257.8±24.3 273.2±185.4 908.4±738.6 46.8±51.3 Spleen 533.1±266.9 529.1±243.6 171.0±9.9 47.4±30.6 180.9±0.0 42.8±53.4 191.2±48.5 206.6±67.6 153.5±42.6 0.00±0.00 0.00±0.00 12.2±24.4 Lung 653.0±306.1 647.4±227.5 95.3±72.0 76.6±46.9 94.5±70.9 16.9±17.7 275.0±101.6 188.3±49.0 125.8±24.7 0.00±0.00 0.00±0.00 0.0±0.0 Kidney 810.3±460.5 933.7±295.8 222.1±41.5 104.7±45.7 180.9±0.0 50.5±40.9 221.2±86.1 264.1±19.6 162.5±38.2 136.3±60.9 0.00±0.00 142.2±47.4 Uterus 565.1±129.8 582.6±130.5 155.1±34.8 140.5±49.2 428.3±47.0 77.7±76.9 261.0±57.0 382.6±83.5 167.0±42.3 133.7±44.6 0.00±0.00 0.00±0.00 Ovary 614.6±341.2 604.9±132.2 91.4±16.3 204.8±42.6 292.9±145.0 98.6±38.8 358.5±78.3 403.5±97.6 224.0±20.2 118.7±68.5 126.0±9.7 0.00±0.00 Muscle 712.2±176.4 663.3±239.3 117.4 ±92.8 55.0±10.7 79.7±49.4 32.9±31.7 154.7±9.7 118.1±82.9 126.4±7.0 0.00±0.00 0.0±0.0 0.00±0.00