Research Article

The Effect of Different Acupuncture Therapies on Neurological Recovery in Spinal Cord Injury: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics of included studies.

AuthorSample size and interventionDuration of SCIOutcome

Wong A. M.50 patients, head + limbs + training; EA via the adhesive surface electrodes; bilateral Hou Hsi (SI3) and Shen Mo (B62); frequency, 75 Hz and pulse duration, 200 sec, 10 mV; each session was 30 min, five sessions per week50 patients, training58.6 ± 17.1 and 57.1 ± 18.7 days, respectively, in two groupsASIA

Qin H. H.22 patients, head + limbs + training; EA on upper 1/5 of parietal temporal anterior oblique (MS6), Piguan (ST31), Liangqiu (ST34), Zusanli (ST36), Fenglong (ST40), Taichong (LR3), Taixi (LI3), and Xuehai (SP10); each session was 20 mins, 100 Hz, once per day; total was 3 months20, limbs + training
3 months
Not mentionedASIA, MBI

Wang S. J.83, back + training; EA on Chongu, Dazhui, Taodao, Shenzhu, Shendao, Zhiyang, Jinsuo, Jizhong, Mingmen, Yaoyangguan, and Xiajishu; once per day for 3 months83, training31∼102 dASIA

Guo X. J.52, back + limbs + training; EA above and below the injured segment, and Huantiao, Zusanli, Yanglingquan, Xuanzhong, Yinlingquan, and Sanyinjiao; 30 min per day, 30 days52, limbs + training
EA on Huantiao, Zusanli, Yanglingquan, Xuanzhong, Yinlingquan, and Sanyinjiao. 30 min per day, 30 days
4 months–4 years in the experiment, 5 months–4.5 years in controlASIA, MBI,

Guan W.43, back + limbs + training; EA on JIanyu, Binao, Quchi, Yangchi, Hegu, Piguan, Futu Zusanli, Fenglong, and Xuanzhong; 20 min per day, 30 days; vitamin B, acupoints injection of methylprednisolone near the injured segment, rehabilitation training for 30 days43, training
Vitamin B, acupoints injection of methylprednisolone near the injured segment, rehabilitation training. 30 days
2.72 ± 2.28 months in the experiment, 2.54 ± 2.43 months in controlASIA, MBI

Jiang H. Y.30, back + training; EA on bilateral Jiaji acupoints. 30 min per day, 80 days; rehabilitation training30, training
Rehabilitation training
3 h–14 d, average (3.1 ± 0.5) d in experiment. 3 h–15 d, average (3.0 ± 0.5) d in controlMBI

Wu K. X.30, back + front + training; EA on bilateral Jiaji acupoints above and below the injured segment, 30 min per day, 7 days per week, 12 weeks; Zhongwan, Xiawan, Qihai, Guanyuan, Wailing, Huaroumen, Qipang, and Xiafengshi, 30 min per day, 3 days per week, 12 weeks30, back + training
EA on bilateral Jiaji acupoints above and below the injured segment, 30 min per day, 7 days per week, 12 weeks
(9.43 ± 7.26) months in experiment, (9.76 ± 6.98) months in controlASIA, MBI

Ou Y. P.42, back + front + limbs; EA on governor meridian and Jiaji points and Jianyu, Quchi, Waiguan, Hegu, Huantiao, Fengshi, Yanglingquan, Jiegu, Taichong, Shenshu, Pangguanshu, Ciliao, Zhongji, Tianshu, Chengshan, Jiexi, Dachangshu, and Changqiang; 30 min per day, 5 times a week, total of 8 weeks; rehabilitation training such as muscle training, balance, and walking42, training
Rehabilitation training such as muscle training, balance, and walking
17–73 d in experiment, 21–70 d in controlMBI

Li X. N.20, back + limbs + training; EA on Jiaji acupoints, Dazhui, Mingmen, Yanglingquan, Zusanli, Shenyu, and Huiyang; 1~2 Hz. 30 min per day20, back + training
EA only on Jiaji acupoints. Rehabilitation training
Not mentionedASIA, MBI
Deng C.20, back + medicine; EA on Zhibian, Huantiao, Piguan, Futu, Yanglingquan, Zusanli, and Kunln; each treatment session was 30 min, 5 times per week, 8 weeks; monosialotetrahexosyl ganglioside sodium 20 mg, iv.qd20, medicine
Monosialotetrahexosyl ganglioside sodium 20 mg, iv.qd
1–6 monthsASIA

Deng N.12, back + limbs + training; EA on governor meridian and Jiaji points above and below the injured site, and Chongmen, Piguan, Huantiao, Weizhong, Zhibian, and Yanglingquan; 2–100 Hz. Each session was 30 min, once per day, 5 times a week, total of 8 weeks12, training
Rehabilitation training
(81.501 ± 6.29) d in experiment, (78.17 ± 6.25) d in controlASIA

Qian Y.38, limbs + training; EA on Shangxing, Shenting, Shenzhu, Baihui, Jizhong, Lingtai, Yaoyangguan, Xuanshu, and Yaoshu; one session was 30 min, 6 times per week, 4 weeks; rehabilitation training38, training
Rehabilitation training and tizanidine hydrochloride tablets
Not mentionedASIA

Sun S. B.20, back + front + limbs + training; Baihui (GV 20), Fengfu (GV 16), Dazhui (GV 14), Zhiyang (GV 9), Mingmen
(GV 4), and Yaoyangguan (GV 3) were selected as the main acupoints; Zhongji (CV 3), Guanyuan (CV 4), Qihai (CV 6), and Guilai (ST 29) were additionally selected for the patients with fecal and urinary incontinence or urinary retention; Jianyu (LI 15), Jianliao (TE 14), Quchi (LI 11), and Hegu (LI 4) were additionally selected for the patients with upper limb dysfunction; Zusanli (ST 36), Xuehai (SP 10), Yanglingquan (GB 34), and Sanyinjiao (SP 6) were additionally selected for the patients with lower limb dysfunction; once a day, 6 times a week, and 12 weeks in total; Conventional rehabilitation training: joint rehabilitation training, exercise rehabilitation training, respiratory training, bladder rehabilitation training, and intestine tract rehabilitation training; once a day, 6 times a week, and 12 weeks in total
20, training
Conventional rehabilitation training: joint rehabilitation training, exercise rehabilitation training, respiratory training, bladder rehabilitation training, and intestine tract rehabilitation training. Once a day, 6 times a week, and 12 weeks in total
2.3–5.4 months in experiment, 2.4–5.2 months in controlASIA

Huo H. X.20, head + back + training; EA on Jiaji points above and below the injured site, and upper 1/5 of parietal temporal anterior oblique (MS6); 30 min per day, 6 days per week, 8 weeks in total; traditional rehabilitation training20, back + training
EA on Jiaji points above and below the injured site. 30 min per day, 6 days per week, and 8 weeks in total. Traditional rehabilitation training
1–3 monthsASIA, MBI
Xiao H.30, back + front + limbs + training; acupuncture on 3 cun above and 2 cun below CV8 of KI and ST meridian in the abdomen, and on the Jiaji points of 3 vertebra segments above and 2 vertebra segments below the injured segment on the back, with the additional points on the limbs bilaterally; acupoints changed every other day on the back and abdomen; 30 mins per day for 3 months; rehabilitation includes strength training, wheelchair driver training, transfer and gait training, practical gait training, and so on30, training
Traditional rehabilitation training
Not mentionedMBI

Xie J. D.43, back + limbs + training; EA on Azhui, Lingtai, Mingmen, Yaoyang, Shousanli, Quchi, Waiguan, Zusanli, Sanyinjiao, Taixi, Yanglingquan, Pangguangshu, Guanyuan, Qihai; 30 min per day, 10 days a session, and followed by a 5-day rest. 6 sessions in total; rehabilitation training43, training
Rehabilitation training
Not mentionedMBI

Guo Y. H.44, back + limbs + training; EA on Dazhui, Lingtai, Mingmen, Yaoyang, Quchi, Waiguan, Hegu, Shousanli, Zusanli, Sanyinjiao, Taixi, Futu, Yanglingquan, Guanyuan, Qihai, Pangguangshu; once per day, each treatment session was 30 min, 10 days a session, and followed by a 5-day rest. 3–5 sessions; rehabilitation training44, training
Rehabilitation training
Not mentionedMBI

Liang T. Y.40, back + front + limbs + training; EA on Dazhui, Mingmen, Lingtai, Yaoyang, Quchi, Waiguan, Shousanli, Taixi, Yanglingquan, Sanyinjiao, Zusanli, Guanyuan, Qihai, Pangguangshu; once per day, each treatment session was 30 min, 10 days a session, and followed by a 5-day rest; 6 sessions in total; rehabilitation training.40, training
Rehabilitation training
Not mentionedMBI

Du Y. P.36, back + limbs + training; EA on Dazhui, Mingmen, Guanyuan, Qihai, Pangguangshu, Lingtai, Yaoyang, Quchi, Waiguan, Shousanli, Taixi, Yanglingquan, Sanyinjiao, Zusanli; once per day, 30 min, 10 days a session, and followed by a 5-day rest. 6 sessions in total; rehabilitation training36, training
Traditional rehabilitation training
Not mentionedMBI

Chen D.20, back + limbs + training. EA on governor meridian and bladder meridian on acupoints above and below the injured site, and acupoints on three yin meridian and three yang meridian; traditional rehabilitation training20, training
Traditional rehabilitation training.
Not mentionedASIA, MBI
Guo J.50, back + limbs + training; EA on Jiaji points and Dazhui, Mingmen, Zusanli, Yanglingquan, Huiyang, Shenshu; each session was 30 min, once per day, 6 times a week, a total of 8 weeks50, training and medicine
Rehabilitation training, herbal steam
(24.6 ± 3 1) d in experiment, (24 5 ± 3.2) d in controlASIA, MBI

Zhao L. S.86, back + front + limbs + training; EA on Shenshu, Mingmen, Guanyuan, Taixi, Zusanli, Pishu; each session was 30 min, once per day, 5 times a week, a total of 4 weeks86, trainingNot mentionedASIA

ASIA: American Spinal Injury Association. MBI: Modified Barthel Index.