Auricular Electrical Stimulation Alleviates Headache through CGRP/COX-2/TRPV1/TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model

<div>Effects of auricular electrical stimulation (ES) pretreatment on depressive or anxiety-like behaviors in the nitroglycerin (NTG)-induced migraine rat model: (a) frequency of rearing behavior (number/5 min); (b) total distance traveled (cm/5 min); (c) percentage of time spent in the inner zone (IT%); (d) percentage of distance traveled in the inner zone (ID%); (e) group mean heat map plot. Color level of duration: the end colors represent the minimum (dark blue) and the maximum (dark red) occupancy of duration. Control: control group; NTG: NTG group; ES: ES group; sham: sham group. 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Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: Auricular Electrical Stimulation Alleviates Headache through CGRP/COX-2/TRPV1/TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model 

Figure 3 | Auricular Electrical Stimulation Alleviates Headache through CGRP/COX-2/TRPV1/TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model 