Evidence-Based Complementary and Alternative Medicine

Research Article

Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa Essential Oils: Chemical Composition, Antimicrobial and Antileishmanial Activity

Table 3

Antileishmanial activity against Leishmania amazonensis and cytotoxicity against BALB/c peritoneal macrophages of Cinnamomum zeylanicum, Curcuma longa, and Origanum vulgare essential oils.


Essential oils/ compounds	L. amazonensis IC₅₀		Cytotoxicity CC₅₀	SI
Essential oils/ compounds	Promastigote (µg/mL)	Intracellular amastigote (µg/mL)	Peritoneal macrophage (µg/mL)	SI

Cinnamomum zeylanicum	>500	n.d.	>1000	n.d.
Curcuma longa	308.4 ± 1.402	63.3 ± 1.369	>1000	>15.79
Origanum vulgare	405.5 ± 1.119	n.d.	>1000	n.d.
Amphotericin B	0.764 ± 0.139	1.045 ± 0.145	37.22 ± 1.834	35.6

Data represents mean ± standard deviation of at least two experiments realized in triplicate. CC₅₀: cytotoxic concentration for 50% of cells; IC₅₀: inhibitory concentration for 50% of parasites; SI: selectivity index; n.d.: not determined. Equal letters in the same column mean statistical difference between IC₅₀ (p<0.0001) by one-way ANOVA and Tukey’s multiple comparisons test.