The Herb-Drug Pharmacokinetic Interaction of Fluoxetine and Its Metabolite Norfluoxetine with a Traditional Chinese Medicine in Rats by LC-MS/MS

Figure 1

Chromatograms: (a) blank plasma; (b) blank plasma with IS; (c) blank plasma with fluoxetine; (d) blank plasma with norfluoxetine; (e) blood sample after oral administration with IS; (f) fluoxetine after oral administration; (g) norfluoxetine after oral administration. Chromatograms (e–g) are based on blood samples collected at 2 h after administration of a combination of FLU and high dose of CSGS (CSGS 23.6 g/kg·d, FLU 1.8 mg/kg·d). The retention times of IS, FLU, and NOF were 2.4, 8.5, and 8.6 min, respectively.

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