The Herb-Drug Pharmacokinetic Interaction of Fluoxetine and Its Metabolite Norfluoxetine with a Traditional Chinese Medicine in Rats by LC-MS/MS

Figure 2

Concentration-time curves of fluoxetine (n = 8, mean ± SD). Fluoxetine group: fluoxetine 1.8 mg/kg·d for consecutive 14 d; multiple dose group A: CSGS 5.9 g/kg·d and fluoxetine 1.8 mg/kg·d for consecutive 14 d; multiple dose group B: CSGS 11.8 g/kg·d and fluoxetine 1.8 mg/kg·d for consecutive 14 d; multiple dose group C: CSGS 23.6 g/kg·d and fluoxetine 1.8 mg/kg·d for consecutive 14 d.