The Herb-Drug Pharmacokinetic Interaction of Fluoxetine and Its Metabolite Norfluoxetine with a Traditional Chinese Medicine in Rats by LC-MS/MS

Table 5

Mean matrix effect of analytes (n = 5).

Composition	Concentration (ng/ml)	Measured C (ng/ml)	Matrix effect (%)	RSD%
FLU	1	1.015 ± 0.027	101.03	2.67
	4	4.011 ± 0.149	100.28	3.71
	16	16.029 ± 0.676	100.18	4.21
NOF	2	1.850 ± 0.079	92.53	4.27
	4	3.834 ± 0.197	95.85	5.13
	8	7.825 ± 0.378	97.81	4.83

FLU: fluoxetine; NOF: norfluoxetine.