The Herb-Drug Pharmacokinetic Interaction of Fluoxetine and Its Metabolite Norfluoxetine with a Traditional Chinese Medicine in Rats by LC-MS/MS

Table 6

Pharmacokinetic parameters of fluoxetine.

Parameter	Unit	Fluoxetine group	Multiple dose group A	Multiple dose group B	Multiple dose group C
AUC (0–∞)	ug/L∗h	12.20 ± 2.67	11.20 ± 3.86	14.54 ± 3.22	22.01 ± 4.49^a
MRT (0–t)	h	7.67 ± 1.02	6.82 ± 0.77	6.88 ± 0.74	10.12 ± 1.11^a
t1/2z	h	8.95 ± 7.50	5.46 ± 0.25	4.93 ± 0.34	8.34 ± 3.31
Tmax	h	0.75	1	1	1
CLz/F	L/h/kg	149.29 ± 28.93	178.71 ± 55.98	130.48 ± 31.64	82.49 ± 12.18^a
Cmax	ug/L	2.19	1.58	2.14	2.38

Fluoxetine group: fluoxetine 1.8 mg/kg·d for consecutive 14 d; multiple dose group A: CSGS 5.9 g/kg·d and fluoxetine 1.8 mg/kg·d for consecutive 14 d; multiple dose group B: CSGS 11.8 g/kg·d and fluoxetine 1.8 mg/kg·d for consecutive 14 d; multiple dose group C: CSGS 23.6 g/kg·d and fluoxetine 1.8 mg/kg·d for consecutive 14 d. , significantly different from the fluoxetine group.