Neuroprotective Effect of Optimized Yinxieling Formula in 6-OHDA-Induced Chronic Model of Parkinson’s Disease through the Inflammation Pathway

<div>Effects of OYF on TNF-<i>α</i>, IL-1<i>β</i>, and IL-6 mRNA levels in <i>in vivo</i> and <i>in vitro</i>. Relative mRNA expression of TNF-<i>α</i> (a), IL-1<i>β</i> (b), and IL-6 (c) in the ipsilateral SN of rats. Relative mRNA expression of TNF-<i>α</i> (d), IL-1<i>β</i> (e), and IL-6 (f) in IFN-<i>γ</i>-induced RAW264.7 cells. Values are expressed as mean ± SD. <i>n</i> = 5-6 per group in the <i>in vivo</i> experiment, <i>n</i> = 3 per group in the <i>in vitro</i> experiment. <svg height="12.1645pt" id="M27" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -11.5275 54.2341 12.1645" width="54.2341pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,4.432,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.013,0,0,-0.013,9.395,0)"><path d="M600 480C600 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Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Neuroprotective Effect of Optimized Yinxieling Formula in 6-OHDA-Induced Chronic Model of Parkinson’s Disease through the Inflammation Pathway 

Figure 5 | Neuroprotective Effect of Optimized Yinxieling Formula in 6-OHDA-Induced Chronic Model of Parkinson’s Disease through the Inflammation Pathway 