Research Article

Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis

Table 2

The overlapping targets for potential targets of the active compounds in DSLHG formula and the liver fibrosis-related targets.

No. Protein nameGene nameUniProt

P1Angiotensin-converting enzymeACEP12821
P2Disintegrin and metalloproteinase domain-containing protein 17ADAM17P78536
P3RAC-alpha serine/threonine-protein kinaseAKT1P31749
P4Serum albuminALBP02768
P5Aldehyde dehydrogenase, mitochondrialALDH2P05091
P6AngiogeninANGP03950
P7Androgen receptorARP10275
P8Aurora kinase AAURKAO14965
P9Bone morphogenetic protein 2BMP2P12643
P10Bone morphogenetic protein 7BMP7P18075
P11Carbonyl reductase [NADPH] 1CBR1P16152
P12Cystathionine beta-synthaseCBSP35520
P13Cyclin-A2CCNA2P20248
P14Cyclin-dependent kinase 2CDK2P24941
P15Cyclin-dependent kinase 6CDK6Q00534
P16Cytochrome P450 2C9CYP2C9P11712
P17Dipeptidyl peptidase 4DPP4P27487
P18Epidermal growth factor receptorEGFRP00533
P19Receptor tyrosine-protein kinase erbB-4ERBB4Q15303
P20Estrogen receptorESR1P03372
P21ProthrombinF2P00734
P22Coagulation factor VIIF7P08709
P23Fatty acid-binding protein, adipocyteFABP4P15090
P24GastrotropinFABP6P51161
P25Fibroblast growth factor receptor 1FGFR1P11362
P26Fibroblast growth factor receptor 2FGFR2P21802
P27GalactokinaseGALK1P51570
P28Vitamin D-binding proteinGCP02774
P29Glycogen synthase kinase-3 betaGSK3BP49841
P30Glutathione S-transferase A1GSTA1P08263
P31Glutathione S-transferase PGSTP1P09211
P32Tyrosine-protein kinase HCKHCKP08631
P33Histone deacetylase 8HDAC8Q9BY41
P34Hexokinase-1HK1P19367
P35Corticosteroid 11-beta-dehydrogenase isozyme 1HSD11B1P28845
P36Estradiol 17-beta-dehydrogenase 1HSD17B1P14061
P37Insulin-like growth factor IIGF1P05019
P38Insulin-like growth factor 1 receptorIGF1RP08069
P39Tyrosine-protein kinase JAK2JAK2O60674
P40Vascular endothelial growth factor receptor 2KDRP35968
P41Tyrosine-protein kinase LckLCKP06239
P42Galectin-3LGALS3P17931
P43Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidaseMAN1B1Q9UKM7
P44Mitogen-activated protein kinase 10MAPK10P53779
P45Mitogen-activated protein kinase 14MAPK14Q16539
P46E3 ubiquitin-protein ligase Mdm2MDM2Q00987
P47Hepatocyte growth factor receptorMETP08581
P48NeprilysinMMEP08473
P49Macrophage metalloelastaseMMP12P39900
P50Collagenase 3MMP13P45452
P51Stromelysin-1MMP3P08254
P52Neutrophil collagenaseMMP8P22894
P53Nitric oxide synthase, endothelialNOS3P29474
P54NAD(P)H dehydrogenase [quinone] 1NQO1P15559
P55Oxysterols receptor LXR-betaNR1H2P55055
P56Bile acid receptorNR1H4Q96RI1
P57Nuclear receptor subfamily 1 group I member 2NR1I2O75469
P58Nuclear receptor subfamily 1 group I member 3NR1I3Q14994
P59Glucocorticoid receptorNR3C1P04150
P60Mineralocorticoid receptorNR3C2P08235
P61Ornithine carbamoyltransferase, mitochondrialOTCP00480
P62Phenylalanine-4-hydroxylasePAHP00439
P63Poly [ADP-ribose] polymerase 1PARP1P09874
P64Phosphoenolpyruvate carboxykinase, cytosolic [GTP]PCK1P35558
P65cAMP-specific 3′,5′-cyclic phosphodiesterase 4BPDE4BQ07343
P66Peroxisome proliferator-activated receptor alphaPPARAQ07869
P67Peroxisome proliferator-activated receptor deltaPPARDQ03181
P68Peroxisome proliferator-activated receptor gammaPPARGP37231
P69Glycogen phosphorylase, liver formPYGLP06737
P70Retinoic acid receptor betaRARBP10826
P71Retinol-binding protein 4RBP4P02753
P72ReninRENP00797
P73GTP-binding protein RhebRHEBQ15382
P74Transforming protein RhoARHOAP61586
P75Nuclear receptor ROR-alphaRORAP35398
P76Retinoic acid receptor RXR-alphaRXRAP19793
P77Alpha-1-antitrypsinSERPINA1P01009
P78Sex hormone-binding globulinSHBGP04278
P79Superoxide dismutase [Mn], mitochondrialSOD2P04179
P80Proto-oncogene tyrosine-protein kinase SrcSRCP12931
P81Signal transducer and activator of transcription 1-alpha/betaSTAT1P42224
P82Bile salt sulfotransferaseSULT2A1Q06520
P83Tyrosine-protein kinase SYKSYKP43405
P84TGF-beta receptor type-1TGFBR1P36897
P85Trafficking protein particle complex subunit 3TRAPPC3O43617
P86TransthyretinTTRP02766