Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis

Table 3

The important signaling pathways of core target genes.

Pathway ID	Term	Target genes	P-Value
hsa04151	PI3K-Akt signaling pathway	AKT1, EGFR, FGFR1, FGFR2, RXRA, MET, IGF1, CDK2, KDR, PCK1, IGF1R, GSK3B, MDM2, NOS3, JAK2	7.21E-0.9
hsa04068	FoxO signaling pathway	AKT1, EGFR, IGF1R, MAPK14, MDM2, IGF1, CDK2, PCK1, SOD2	1.14E-06
hsa04014	Ras signaling pathway	AKT1, EGFR, IGF1R, FGFR1, FGFR2, MET, RHOA, IGF1, KDR	5.39E-05
hsa04919	Thyroid hormone signaling pathway	AKT1, RXRA, GSK3B, ESR1, MDM2, STAT1, SRC	6.15E-05
hsa04015	Rap1 signaling pathway	AKT1, EGFR, FGFR2, IGF1R, FGFR1, MAPK14, MET, RHOA, IGF1, SRC, KDR	3.55E-07
hsa04510	Focal adhesion	AKT1, EGFR, IGF1R, GSK3B, MET, RHOA, IGF1, SRC, KDR	2.77E-05
hsa05205	Proteoglycans in cancer	AKT1, EGFR, IGF1R, FGFR1, ERBB4, MAPK14, MET, RHOA, ESR1, MDM2, IGF1, SRC, KDR	1.35E-09
hsa05200	Pathways in cancer	AKT1, EGFR, FGFR2, FGFR1, AR, BMP2, RXRA, MET, PPARG, IGF1, STAT1, CDK2, IGF1R, GSK3B, RHOA, MDM2, GSTP1	4.03E-10
hsa05215	Prostate cancer	AKT1, FGFR2, EGFR, IGF1R, FGFR1, AR, GSK3B, MDM2, IGF1, CDK2	1.91E-09
hsa04066	HIF-1 signaling pathway	AKT1, EGFR, IGF1R, IGF1, HK1, NOS3	2.70E-04