Inhibition of Cytochrome P450 Activities by Sophora flavescens Extract and Its Prenylated Flavonoids in Human Liver Microsomes

Figure 3

Concentration-dependent inhibition of CYP isoforms by S. flavescens extract and its prenylated flavonoids in human liver microsomes with (○) or without (●) preincubation in the presence of an NADPH-generating system. CYP activities are expressed as the relative percentage of the activity in the control. Each data point represents the mean of triplicate experiments.