Research Article
Inhibition of Cytochrome P450 Activities by Sophora flavescens Extract and Its Prenylated Flavonoids in Human Liver Microsomes
Table 1
. CYP isoform-selective substrates, concentrations, and corresponding metabolites.
| | CYP isoform | Substrate | Concentration used (μM) | Metabolites |
| | 1A2 | Phenacetin | 50 | Acetaminophen | | 2A6 | Coumarin | 5 | 7-Hydroxycoumarin | | 2B6 | Bupropion | 50 | 6-Hydroxybupropion | | 2C8 | Rosiglitazone | 5 | Hydroxyrosiglitazone | | 2C9 | Diclofenac | 10 | Hydroxydiclofenac | | 2C19 | S-Mephenytoin | 80 | 4-Hydroxymephenytoin | | 2D6 | Dextromethorphan | 5 | Dextrorphan | | 3A4 | Midazolam | 2 | 1-Hydroxymidazolam | | | | | - |
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