Research Article
Inhibition of Cytochrome P450 Activities by Sophora flavescens Extract and Its Prenylated Flavonoids in Human Liver Microsomes
Table 2
IC50 values of the standardized hop extract and individual prenylated flavonoids for inhibition of specific CYP isoforms in human liver microsomes.
| CYP isoform | Preincubation | IC50 value | S. flavescens extract (μg/mL) | Kushenol A (μM) | Kushenol C (μM) | Kushenol I (μM) | Kushenol M (μM) | Leachianone A (μM) | Sophoraflavone G (μM) |
| 1A2 | - | >100 | >50 | 5.00 | >50 | >50 | >50 | 2.26 | + | 54.6 | >50 | 4.86 | >50 | >50 | >50 | 0.17 | 2A6 | - | >100 | >50 | >50 | >50 | >50 | >50 | >50 | + | >100 | >50 | >50 | >50 | >50 | >50 | >50 | 2B6 | - | 66.5 | >50 | >50 | >50 | >50 | 5.74 | 2.42 | + | 0.7 | >50 | >50 | 0.12 | >50 | 0.28 | 0.07 | 2C8 | - | 1.42 | >50 | >50 | 0.67 | >50 | 0.75 | 0.32 | + | 0.49 | 0.11 | 7.07 | 0.14 | 0.28 | 0.33 | 0.09 | 2C9 | - | 13.6 | >50 | 9.3 | 7.35 | >50 | >50 | 1.25 | + | 12.3 | 2.5 | 6.9 | 5.03 | >50 | 2.05 | 0.42 | 2C19 | - | 19.1 | >50 | >50 | >50 | >50 | >50 | N.D | + | 18.7 | >50 | 6.6 | >50 | >50 | 3.13 | N.D | 2D6 | - | >100 | >50 | >50 | >50 | >50 | >50 | >50 | + | 73.4 | >50 | >50 | >50 | >50 | >50 | >50 | 3A4 | - | 51.0 | >50 | >50 | >50 | >50 | >50 | >50 | + | 6.2 | >50 | 3.95 | 0.57 | 1.29 | 0.69 | 0.78 |
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