Studies Data Sources Time Detailed search strategy Search process Number of studies Number of patients Bias assessment tool Outcomes Report publication bias Hong Pan et al. 2018 [26 ] Embase, Medline, the Cochrane library, ScicenceDirect, PubMed, AMED, CBM, Wanfang, CNKI, VIP Before April 2017 Yes Two reviewers independently 35 1517/146 Cochrane Collaboration's risk of bias tool clinical therapeutic effect, BMD, Pain VAS, Serum Calcium, Serum Alkaline Phosphatase, E2 Funnel plot Jinfeng Chen et al. 2018 [27 ] PubMed, CNKI, CBM, VIP, Wanfang Before November 2016 Yes Not mention 12 515/481 Jadad Scale clinical therapeutic effect, BMD, Pain scale, BGP, Serum Alkaline Phosphatase, safety Funnel plot Ding Luo et al. 2018 [5 ] Medline, Embase, Cochrane Library, Web of Science, CNKI, the Chinese VIP database and Wangfang database Before June 30, 2016 Yes Two reviewers independently 9 303/26 Cochrane Collaboration's risk of bias tool BMD of lumbar vertebrae, BMD of femoral neck, Ward’s triangle and greater Trochanter, pain VAS None Xiaotong Wang et al. 2018 [28 ] CNKI, Wanfang, CBM, VIP, PubMed Before June 1, 2016 Yes Two reviewers independently 4 93/93 Cochrane Collaboration's risk of bias tool clinical therapeutic effect, BMD, E2, BGP, Ca/Cr None Ding Luo et al. 2017 [29 ] CNKI, Wanfang, VIP, PubMed, Embase, The Cochrane Central Register of Controlled Trials Before October 1, 2016 None Not mention 23 959/91 Cochrane Collaboration's risk of bias tool clinical therapeutic effect, Pain scale, BMD of lumbar vertebra, E2, testosterone, BGP, TCM symptom score Funnel plot, Egger’s test Yanan Wu et al. 2017 [30 ] CNKI, Wanfang, VIP, PubMed, EMBASE, The Cochrane Central Register of Controlled Trials Before December 1, 2015 None Two reviewers independently 11 487/485 Cochrane Collaboration's risk of bias tool Pain scale, BMD of lumbar vertebra, TCM symptom score, effectiveness Funnel plot, Egger’s test Li Xiao et al. 2016 [31 ] CNKI, VIP, Wanfang, CBM, PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Embase 2006.1-2016.7 None Two reviewers independently 10 477/47 Jadad Scale clinical therapeutic effect, E2, BMD Funnel plot Longyun Zhou et al. 2016 [32 ] CNKI, VIP, CBM, Wanfang, Chinese Clinical Trial Registry, PubMed, Cochrane Library, Web of Science, Embase, AMED Before September 1, 2015 Yes Two reviewers independently 16 658/606 Jadad Scale clinical therapeutic effect, Pain measurement, BMD, safety Funnel plot Sheng Li et al. 2014 [33 ] CNKI, VIP, Wanfang, CBM, and Luzhou Medical College Library Before October 1, 2013 None Not mention 9 365/322 Jadad Scale clinical therapeutic effect, BMD, E2 None Juntao Xu et al. 2014 [34 ] CNKI, VIP, Wanfang 2003-2011 None Not mention 9 373/371 Jadad Scale clinical therapeutic effect, bone pain, BMD of lumbar vertebra None
