Evidence-Based Complementary and Alternative Medicine

Review Article

A Review of Danshen Combined with Clopidogrel in the Treatment of Coronary Heart Disease

Table 3

Inhibition ( IC₅₀) of Danshen's effective components on different CYP450 isozymes in human liver microsomes.


Components	type of Probe	IC₅₀ ( μM )										References
Components	type of Probe	CYP1A2	CYP2B6	CYP2C9	CYP2C9 1	CYP2C9 2	CYP2C9 3	CYP2C19	CYP2D6	CYP3A4	P450 2J2	References

Tanshinone IIA	1, 3 - 7, 9	1.3- 10.10	-	> 100	-	-	-	> 100	13.47, > 200	> 100	2.5	[43–47]
Cryptotanshinone	1, 3 - 7, 10	0.75 - 3.06	-	23.86-33	1. 74	2. 64	3. 17	> 100	75	> 100	-	[43, 44, 47, 48]
Miltirone	1, 4 - 6, 8	1.73	-	8.61	-	-	-	26.9	30.20	33.88	-	[43, 49]
Dihydrotanshinone	1, 2, 4 - 8, 10	0.5- 2.25	2. 64	7.48	0. 19	0. 56	1. 52	0.6	11.70-35.4	0.367-3.22	-	[43–45, 48, 50]
Tanshinone I	1, 3 - 7	0.75-11.61	-	> 100	-	-	-	> 100	> 100	> 100	-	[43–45, 47]
Salvianolic acid A	1, 5	5. 37	-	-	-	-	-	-	11. 53	-	-	[45]
Salvianolic acid B	1, 3, 5 - 7	> 100	-	> 200	-	-	-	-	> 200	12. 35 > 200	-	[45, 47]
Rosmarinic acid	1, 7	10. 32	-	-	-	-	-	-	-	5. 43	-	[45]
Danshensu	1, 3, 5 - 7	> 100	-	50	-	-	-	-	> 200	> 200	-	[47]

-, currently not available.
1: Phenacetin; 2: Mephenytoin; 3: Diclofenac; 4: Tolbutamide; 5: Dextromethorphan; 6: Testosterone; 7: Midazolam; 8: Omeprazole; 9: Astemizole; 10: Fluvastatin.