Role for Endocannabinoids in Spinal Manipulative Therapy Analgesia?

Figure 1

Mean mechanical thresholds (grams) on 15-18 days following spared nerve injury (Baseline) and at 15-90 minutes (min) after intraperitoneal injections of vehicle and then vehicle (V + V), AM281 and then vehicle (A + V), vehicle and then URB597 (V + U), or AM281 and then URB597 (A + U). Data are presented as means and 95% confidence intervals from the linear mixed-effects model. Vehicle and then URB597 significantly increased mean mechanical thresholds compared to the Vehicle group at the 15 (P < 0.001), 25 (P < 0.001), 40 (P = 0.002), 55 (P = 0.02), and 70 (P = 0.01) min time-points, but not at the 90 min time-point (P = 0.11). Vehicle and then URB597 significantly increased mean mechanical thresholds compared to the AM281 and then vehicle group at the 15 (P = 0.002), 25 (P = 0.001), 40 (P = 0.001), 70 (P = 0.05), and 90 (P = 0.02) min time-points, but not at the 55 min time-point (P = 0.09). Vehicle and then URB597 significantly increased mean mechanical thresholds compared to the AM281 and then URB597 group at the 15 (P = 0.001), 25 (P = 0.001), 40 (P = 0.001), and 90 (P = 0.03) min time-points, but not at the 55 (P = 0.25) or 70 (P = 0.06) min time-points.