Antihypertensive Activity of Leersia hexandra Sw. (Poaceae) Aqueous Extract on Ethanol-Induced Hypertension in Wistar Rat

Table 2

Effects of the aqueous extract of L. hexandra on hemodynamic parameters.

Parameters	NTR	HTR	Nif. 10	L h 100	L h 200
SBP (mmHg)	112.50 ± 0.86	175.02 ± 2.64^3	118.50 ± 2.25	100.20 ± 1.83	117.20 ± 1.13
DBP (mmHg)	101.53 ± 1.54	160.52 ± 2.67^3	105.40 ± 1.81	91.08 ± 3.73	104.40 ± 1.97
MBP (mmHg)	105.20 ± 1.50	165.35 ± 2.64^3	109.80 ± 0.85	94.13 ± 2.51	108.70 ± 1.28
HR (BPM)	320.10 ± 1.60	346.20 ± 2.33^3	347.83 ± 1.15^3	347.70 ± 2.20^3	345.60 ± 1.18^3

Each value represents the mean ± SEM (n = 5). BPM: beat per minute, SBP: systolic blood pressure, DBP: diastolic blood pressure, MBP: mean blood pressure, HR: heart rate, and NTR: normotensive rats receiving distilled water (10 mL/kg), HRT: hypertensive rats receiving distilled water (10 mL/kg) and alcohol (5 g/kg), L h 100 and L h 200: hypertensive rats receiving ethanol and Leersia hexandra extract at the doses of 100 and 200 mg/kg, respectively, and Nif. 10: hypertensive rats receiving alcohol and nifedipine at the dose of 10 mg/kg; 1: p <0.05 and 3: p <0.001: significant difference from normotensive rats; c: p <0.001: significant difference from hypertensive rats.