Protium javanicum Burm. Methanol Extract Attenuates LPS-Induced Inflammatory Activities in Macrophage-Like RAW264.7 Cells

Figure 5

Putative suppressive pathway of Pj-ME in displaying its anti-inflammatory response. It is considered that Pj-ME targets the activation of protein tyrosine kinases such as JAK and Src and Syk linked to the activation of intracellular signaling pathway for the nuclear translocation of NF-κBand STAT3. Suppression of this pathway leads to the downregulation of iNOS-mediated NO production and the expression of other cytokines such as NO and IL-6.