Uncovering the Pharmacological Mechanism of Chaibei Zhixian Decoction on Epilepsy by Network Pharmacology Analysis

Figure 1

PPIN (action view) showing CZD targets. The colored edges indicate the nature of action, as interpreted here: activation (), inhibition (), binding (), catalysis (), phenotype (), posttranslational modification (), reaction (), and transcriptional regulation (). The effects of action are represented by the following symbols: positive (), negative (), and unspecified (). AXIN1: axin 1; NCOA3: nuclear receptor coactivator 3; BRCA1: breast cancer 1, early onset; CHRM1: cholinergic receptor, muscarinic 1; CHRM5: cholinergic receptor, muscarinic 5; ESR1: estrogen receptor 1; CTNNB1: catenin (cadherin-associated protein), beta 1; CYP1A2: cytochrome P450, family 1, subfamily A, polypeptide 2; ESR2: estrogen receptor 2; HTR2A: 5-hydroxytryptamine (serotonin) receptor 2A; GSK3B: glycogen synthase kinase 3 beta; MAPK1: mitogen-activated protein kinase 1; MAPK3: mitogen-activated protein kinase 3; HTR2C: 5-hydroxytryptamine (serotonin); MAPT: microtubule-associated protein tau; SP1: Sp1 transcription factor; receptor 2C; NTF4: neurotrophin 4; EP300: E1A binding protein p300; NTRK2: neurotrophic tyrosine kinase, receptor, type 2; SLC6A4: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; SRC: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian).