Electroacupuncture Improves Antidepressant Effects in CUMS Rats by Protecting Hippocampal Synapse and Mitochondrion: An Ultrastructural and iTRAQ Proteomic Study
EA+SSRI reverses postsynaptic density loss and mitochondrial lesion during depression. (a) CUMS caused PSD loss in hippocampal neuron. EA and SSRI alone reversed the loss while EA was more effective. EA+SSRI induced more PSD increase compared with EA or SSRI alone. Asterisks (): presynaptic vesicles; arrowheads: postsynaptic density (n = 3 rats/group); × 80,000. (b) Exposed to CUMS, mitochondria in hippocampal neuron were enlarged and contain fragments of cristae. EA, SSRI, and EA+SSRI reversed mitochondrial damage (n = 3 rats/group). M: mitochondria. Arrowheads: cristae dissolve; × 24,000.
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