Electroacupuncture Improves Antidepressant Effects in CUMS Rats by Protecting Hippocampal Synapse and Mitochondrion: An Ultrastructural and iTRAQ Proteomic Study
EA causes synaptic proteins and mitochondrial electron transport chain proteins change in depressed rats. (a) Synaptic proteins EA changed are mainly involved in PSD and synaptic vesicle. 5 synaptic vesicle proteins changed after EA, among which 2 were upregulated, while 3 were downregulated. 6 proteins concerning PSD were changed, and 4 of them were upregulated, while 2 were downregulated. (b) Among the differential expressed proteins distributed in mitochondria 2 of the proteins that consist of NADH dehydrogenase were upregulated while 5 were downregulated. In cytochrome c oxidase, 1 was upregulated, while 4 were downregulated. Only 1 protein that belongs to ATP synthase changed and it was upregulated. : upregulated protein number. : downregulated protein number. PSD: postsynaptic density.
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