Electroacupuncture Improves Antidepressant Effects in CUMS Rats by Protecting Hippocampal Synapse and Mitochondrion: An Ultrastructural and iTRAQ Proteomic Study
Figure 4
EA causes synaptic proteins and mitochondrial electron transport chain proteins change in depressed rats. (a) Synaptic proteins EA changed are mainly involved in PSD and synaptic vesicle. 5 synaptic vesicle proteins changed after EA, among which 2 were upregulated, while 3 were downregulated. 6 proteins concerning PSD were changed, and 4 of them were upregulated, while 2 were downregulated. (b) Among the differential expressed proteins distributed in mitochondria 2 of the proteins that consist of NADH dehydrogenase were upregulated while 5 were downregulated. In cytochrome c oxidase, 1 was upregulated, while 4 were downregulated. Only 1 protein that belongs to ATP synthase changed and it was upregulated. : upregulated protein number. : downregulated protein number. PSD: postsynaptic density.