Panax ginseng Inhibits Metabolism of Diester Alkaloids by Downregulating CYP3A4 Enzyme Activity via the Pregnane X Receptor

Figure 5

Concentration-velocity curves of aconitine (a), mesaconitine (b), and hypaconitine (c) metabolism after incubation with recombinant human cytochrome P450 enzymes (n = 3). The incubation conditions are described in the Materials and Methods section. The curve was automatically fitted using nonlinear regression and the Michaelis–Menten equation.

(a)

(b)

(c)