Research Article
Panax ginseng Inhibits Metabolism of Diester Alkaloids by Downregulating CYP3A4 Enzyme Activity via the Pregnane X Receptor
Table 2
Effect of P. ginseng on the pharmacokinetics of caffeine on day 7 after administration.
| Parameters/unit | Control | P. ginseng-L | P. ginseng-M | P. ginseng-H |
| /mg.L-1.h | 2.28 ± 0.62 | 6.44 ± 2.32 | 8.20 ± 1.41 | 3.54 ± 0.84 | /mg.L-1.h | 2.62 ± 0.55 | 7.07 ± 2.35 | 11.99 ± 3.16 | 3.86 ± 0.81 | /h | 0.48 ± 0.31 | 0.60 ± 0.21 | 1.06 ± 0.36 | 0.46 ± 0.13 | /mg.L−1 | 0.28 ± 0.19 | 0.11 ± 0.07 | 0.08 ± 0.00 | 0.17 ± 0.09 | /L.h-1.kg−1 | 7.94 ± 1.76 | 0.39 ± 0.15 | 0.22 ± 0.06 | 0.68 ± 0.18 | /mg.L−1 | 3.04 ± 0.29 | 7.49 ± 2.56 | 10.38 ± 2.43 | 4.56 ± 1.14 |
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Note: compared with the control group, < 0.05; < 0.01. |