Research Article
Panax ginseng Inhibits Metabolism of Diester Alkaloids by Downregulating CYP3A4 Enzyme Activity via the Pregnane X Receptor
Table 3
Effect of P. ginseng on the pharmacokinetics of tolbutamide on day 7 after administration.
| Parameters/unit | Control | P. ginseng-L | P. ginseng-M | P. ginseng-H |
| /mg.L-1.h | 263.69 ± 21.75 | 236.95 ± 30.48 | 259.24 ± 33.53 | 287.59 ± 52.61 | /mg.L-1.h | 273.05 ± 25.6 | 265.70 ± 28.38 | 288.31 ± 35.17 | 314.43 ± 59.49 | /h | 4.86 ± 0.80 | 7.71 ± 2.71 | 7.59 ± 2.24 | 6.93 ± 1.00 | /mg.L−1 | 0.42 ± 0.46 | 0.08 ± 0.00 | 0.08 ± 0.00 | 0.24 ± 0.15 | /L.h-1.kg−1 | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 | /mg.L−1 | 38.71 ± 5.56 | 38.76 ± 9.51 | 55.91 ± 7.86 | 42.96 ± 7.88 |
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Note: compared with the control group, < 0.05; < 0.01. |