Research Article
Panax ginseng Inhibits Metabolism of Diester Alkaloids by Downregulating CYP3A4 Enzyme Activity via the Pregnane X Receptor
Table 4
Effect of P. ginseng on the pharmacokinetics of chlorzoxazone on day 7 after administration.
| Parameters/unit | Control | P. ginseng-L | P. ginseng-M | P. ginseng-H |
| /mg.L-1.h | 13.53 ± 2.42 | 9.37 ± 1.93 | 19.05 ± 4.28 | 16.72 ± 5.96 | /mg.L-1.h | 20.50 ± 6.59 | 11.89 ± 3.80 | 20.45 ± 5.10 | 18.39 ± 5.55 | /h | 0.59 ± 0.25 | 0.40 ± 0.24 | 0.47 ± 0.11 | 0.30 ± 0.08 | /mg.L−1 | 0.11 ± 0.07 | 0.08 ± 0.00 | 0.08 ± 0.00 | 0.17 ± 0.09 | /L.h-1.kg−1 | 1.07 ± 0.37 | 1.85 ± 0.64 | 1.02 ± 0.21 | 1.17 ± 0.34 | /mg.L−1 | 21.32 ± 2.54 | 14.79 ± 2.28 | 28.51 ± 4.92 | 25.08 ± 6.49 |
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Note: compared with the control group, < 0.05; < 0.01. |