Panax ginseng Inhibits Metabolism of Diester Alkaloids by Downregulating CYP3A4 Enzyme Activity via the Pregnane X Receptor

Table 4

Effect of P. ginseng on the pharmacokinetics of chlorzoxazone on day 7 after administration.

Parameters/unit	Control	P. ginseng-L	P. ginseng-M	P. ginseng-H
/mg^.L^-1.h	13.53 ± 2.42	9.37 ± 1.93	19.05 ± 4.28	16.72 ± 5.96
/mg^.L^-1.h	20.50 ± 6.59	11.89 ± 3.80	20.45 ± 5.10	18.39 ± 5.55
/h	0.59 ± 0.25	0.40 ± 0.24	0.47 ± 0.11	0.30 ± 0.08
/mg^.L^−1	0.11 ± 0.07	0.08 ± 0.00	0.08 ± 0.00	0.17 ± 0.09
/L^.h^-1.kg^−1	1.07 ± 0.37	1.85 ± 0.64	1.02 ± 0.21	1.17 ± 0.34
/mg^.L^−1	21.32 ± 2.54	14.79 ± 2.28	28.51 ± 4.92	25.08 ± 6.49

Note: compared with the control group, < 0.05; < 0.01.