MicroRNAs in the Progress of Diabetic Nephropathy: A Systematic Review and Meta-Analysis

Table 1

Main characteristics of the reports included in the study; expression of miRNAs in DN groups.

Author	Year	Country	Methods	Samples	Case Number				MiRNAs	Expression
					N	NA	MA	MAA
McClelland et al.	2015	Australia	qRT-PCR	FFPE	35	8			miR-21	up
Huang et al.	2014	China	qRT-PCR	biopsy	3	6			miR-155,miR-146a	up
Koga et al.	2015	Japan	qRT-PCR	biopsy				11	miR-26a	down
Eissa et al.	2016	Egypt	qRT-PCR	urinary exosomes	54	56	66	44	miR-133b,miR-342,miR-30	up
Bijkerk et al.	2015	Netherlands	qRT-PCR	plasma	19	21			miR-181a,miR-326	up
									miR-223,miR-574-3p	down
Federica	2015	Italy	qRT-PCR	urinary exosomes			12	12	miR-145,miR-130a	up
									miR-155,miR-424	down
Kafaji et al.	2016	Bahrain	qRT-PCR	whole blood	50		29	21	miR-126	down
Ma et al.	2016	China	qRT-PCR	serum	127	157	159	148	miR-192	down
Jia et al.	2016	China	qRT-PCR	urinary	10	30	20	30	miR-192,miR-194,miR-215	up
Barutta et al.	2016	Italy	qRT-PCR	serum	143		74	105	miR-126	down
Shao et al.	2016	China	qRT-PCR	serum	195	186	169	140	miR-217	up
Eissa et al.	2016	Egypt	qRT-PCR	urinary exosomes	44	46	90		miR-15b,miR-34a,miR-636	up