In Vitro Anti-Inflammatory and In Vivo Antiarthritic Activities of Aqueous and Ethanolic Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Rats

Table 2

Effect of aqueous and ethanolic extracts of Dissotis thollonii on protein denaturation, cyclooxygenase inhibition, and 5-lipoxygenase inhibition.

Compounds	Dose (μg/ml)	Inhibition (%)
		Protein denaturation	Cyclooxygénase	5-lipoxygénase
Diclofenac	100	74.41	—	—
	200	76.72	—	—
	500	81.48	—	—
	1000	89.19	—	—
Ibuprofen	100	—	83.46	82.03
	200	—	89.90	88.63
	500	—	93.39	92.96
	1000	—	97.88	95.31
Aqueous extract	100	27.33	24.72	31.26
	200	29.26	34.14	45.60
	500	33.83	40.70	58.17
	1000	42.51	47.07	66.79
Ethanolic extract	100	30.87	28.14	36.12
	200	32.79	40.89	48.24
	500	37.30	53.55	64.11
	1000	44.44	63.36	77.48

The percentage values were obtained using various concentrations of test compounds, and readings are presented as mean of triplicates.