In Vitro Anti-Inflammatory and In Vivo Antiarthritic Activities of Aqueous and Ethanolic Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Rats

Table 3

IC₅₀ value of aqueous and ethanolic extracts of Dissotis thollonii on human whole blood evaluated by luminal-amplified chemiluminescence.

	Oxidative burst (IC50 (μg/ml))			T-cell proliferation (IC50 (μg/ml))
	WB	PMNs	MQ
Aqueous extract	>100	5.74 ± 0.65	7.47 ± 2.68	16.89 ± 2.55
Ethanolic extract	4.89 ± 0.49	2.96 ± 0.12	3.28 ± 0.09	3.29 ± 1.96
Ibuprofen	12.71 ± 0.13	12.53 ± 0.21	13.28 ± 1.07	—
Prednisolone	—	—	—	<3.10

The IC₅₀ values were obtained using various concentrations of test compounds, and readings are presented as mean ± SD of triplicates. WB: whole blood; PMNs: polymorphonuclear leukocytes; MQ: mice peritoneal macrophages.