In Vitro Anti-Inflammatory and In Vivo Antiarthritic Activities of Aqueous and Ethanolic Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Rats
Table 5
Effect of aqueous and ethanolic extracts of Dissotis thollonii on serum parameters in CFA-induced arthritis in rats.
Treatment
Dose (mg/kg)
ALT (U/I)
AST (U/I)
ALP (U/I)
Creatinine (μmol/l)
Total protein (g/dl)
Healthy control
—
47.09 ± 1.91
173.89 ± 11.61
90.27 ± 3.36
0.48 ± 0.07
7.45 ± 0.24
Arthritic control
—
77.88 ± 2.07λ
423.09 ± 23.51λ
444.38 ± 13.69λ
1.39 ± 0.13λ
5.90 ± 0.17β
Diclofenac
5
63.46 ± 1.50λc
250.70 ± 16.76βc
240.11 ± 16.28λc
0.93 ± 0.03λc
6.65 ± 0.28
Aqueous extract
250
63.97 ± 1.72λc
299.79 ± 11.76λc
317.40 ± 17.20λc
0.98 ± 0.05λc
6.35 ± 0.34
500
55.14 ± 1.16αc
222.59 ± 6.07c
207.33 ± 9.89λc
0.69 ± 0.03c
7.31 ± 0.19a
Ethanolic extract
250
55.41 ± 1.84αc
253.30 ± 2.77βc
270.97 ± 7.43λc
0.86 ± 0.3βc
7.16 ± 0.29a
500
46.12 ± 1.42c
177.62 ± 7.62c
143.00 ± 5.34c
0.60 ± 0.02c
7.54 ± 0.28b
CFA: complete Freund’s adjuvant; ALP: alkaline phosphatase; AST: aminotransferase; ALT: alanine aminotransferase. Each value represents the mean ± ESM for six animals and analyses by one-way ANOVA followed by Bonferroni post hoc test, α,β,λ when compared with the healthy control and a,b,c when compared with the arthritic control.