In Vitro Anti-Inflammatory and In Vivo Antiarthritic Activities of Aqueous and Ethanolic Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Rats

Table 6

Effect of aqueous and ethanolic extracts of Dissotis thollonii on some parameters of oxidative stress in CFA-induced arthritis in rats.

Treatment	Dose (mg/kg)	NO (μM)	Glutathion (×10^3 activity)	Catalase (activity)	MDA (×10^3 mol/l)	SOD (activity)
Healthy control	—	0.048 ± 0.003	0.28 ± 0.03	52.99 ± 0.67	0.087 ± 0.021	1.93 ± 0.02
Arthritic control	—	0.089 ± 0.003^λ	0.17 ± 0.01^β	36.89 ± 0.72^λ	0.138 ± 0.027	1.51 ± 0.03^λ
Diclofenac	5	0.044 ± 0.001^c	0.21 ± 0.01	37.72 ± 0.74^γ	0.112 ± 0.035	1.92 ± 0.03^c
Aqueous extract	250	0.073 ± 0.005^λa	0.18 ± 0.02^β	45.33 ± 0.97	0.127 ± 0.020	1.93 ± 0.02^c
	500	0.064 ± 0.003^αc	0.24 ± 0.01	51.45 ± 1.70^c	0.109 ± 0.038	1.95 ± 0.04^c
Ethanolic extract	250	0.067 ± 0.001^βc	0.22 ± 0.01	48.95 ± 1.18^c	0.125 ± 0.005	1.94 ± 0.02^c
	500	0.046 ± 0.003^c	0.27 ± 0.01^b	52.39 ± 4.09^c	0.071 ± 0.020	1.95 ± 0.08^c

Each value represents the mean ± ESM for six animals and analyses by one-way ANOVA followed by Bonferroni post hoc test, ^α, ^β, and ^λ when compared with the healthy control and ^a, ^c when compared with the arthritic control.