Water Extract of Acori Graminei Rhizoma Attenuates Features of Rheumatoid Arthritis in DBA/1 Mice

Figure 4

Effect of WAG administration on the level of blood neutrophil and infiltration of inflammatory cell in synovial membrane. Mice were separated into five groups (NOR; n=10, Control (CIA); n=10, 0.2 mg/kg MTX; n=10, 100 mg/kg WAG; n=10, 500 mg.kg WAG; n=10). (a-b) Blood neutrophils were analyzed by IDEXX ProCyte. Data represent the mean ± SEM of three independent experiments. (c) Representative images were stained by hematoxylin and eosin (H&E) staining; infiltration of inflammatory cell was indicated with black arrowhead. Means with difference letters are significantly different at ^#p < 0.05 vs. normal group; p < 0.05 vs. CIA group by one-way ANOVA with Tukey post hoc test. CIA, collagen induced arthritis; MTX, methotrexate; WAG, water extracts of Acori Graminei Rhizoma.