Water Extract of Acori Graminei Rhizoma Attenuates Features of Rheumatoid Arthritis in DBA/1 Mice

Figure 5

Effect of WAG on CIA-induced induction of inflammatory cytokines and type II collagen IgG in serum. Mice were separated into five groups (NOR; n=10, Control (CIA); n=10, 0.2 mg/kg MTX; n=10, 100 mg/kg WAG; n=10, 500 mg.kg WAG; n=10). (a-c) IL-6, TNF-alpha, and type II collagen IgG were analyzed by ELISA assay. Means with difference letters are significantly different at ^#p < 0.05 vs. normal group; p < 0.05 vs. CIA group by one-way ANOVA with Tukey post hoc test. CIA, collagen induced arthritis; MTX, methotrexate; WAG, water extracts of Acori Graminei Rhizoma.

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