Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models

Table 11

Hematological cytologic marker values of rats treated with CHB-II-F after 2 weeks of recovery period in the sub-chronic toxicity test.

Parameters	Dose (g/kg)
	Control	26.20	13.10	6.55
Male
WBC (10^9/L)	3.88±1.08	2.03±0.51	4.32±1.10	5.63±2.11
Neu (%)	29.60±9.01	30.60±9.36	19.88±6.23	20.50±4.09
Lym (%)	65.95±9.07	65.25±10.34	77.75±6.78	76.53±4.63
Mon (%)	2.95±0.49	2.25±0.99	1.00±0.38	2.05±0.89
Eos (%)	1.18±0.23	1.63±0.74	1.75±0.45	0.78±0.25
Bas (%)	0.33±0.06	0.28±0.03	0.20±0.04	0.25±0.03
RBC (10^12/L)	7.81±0.15	7.55±0.56	7.98±0.22	8.16±0.24
HGB (g/L)	143.00±4.18	135.00±6.01	138.75±2.75	147.25±2.75
HCT (%)	42.25±1.06	41.50±2.69	42.53±0.88	43.68±1.10
MCV (fL)	54.13±0.70	55.13±1.02	53.35±0.95	53.53±0.32
MCH (pg)	18.38±0.30	18.00±0.59	17.40±0.29	18.03±0.21
MCHC (g/L)	339.00±3.44	326.50±8.14	326.25±1.03	336.50±2.22
PLT (10^9/L)	995.00±30.73	915.75±56.34	1045.00±87.99	885.25±32.70
Female
WBC (10^9/L)	1.32±0.36	1.39±0.18	2.62±0.53	1.62±0.42
Neu (%)	21.95±4.44	32.50±6.46	17.80±5.32	17.55±1.51
Lym (%)	70.45±8.02	59.73±8.03	79.15±5.72	80.10±1.08
Mon (%)	6.23±3.55	4.30±0.66	1.75±0.13	1.63±0.64
Eos (%)	1.08±0.33	3.28±1.42	1.08±0.45	0.48±0.12
Bas (%)	0.30±0.11	0.20±0.04	0.23±0.06	0.25±0.03
RBC (10^12/L)	7.05±0.15	7.08±0.37	6.90±0.37	7.15±0.11
HGB (g/L)	137.00±1.47	131.50±2.90	132.00±5.40	136.25±3.07
HCT (%)	39.60±0.09	39.50±1.05	39.53±0.97	40.05±0.52
MCV (fL)	56.23±1.05	56.10±1.75	57.55±1.88	55.98±0.46
MCH (pg)	19.48±0.33	18.73±0.72	19.15±0.42	19.08±0.30
MCHC (g/L)	346.00±3.19	333.50±2.75	333.50±7.37	340.00±4.74
PLT (10^9/L)	1025.50±115.74	880.75±77.51	1065.00±84.52	857.25±92.28

Note: Data were presented as the mean ±SD from 6 rats. No statistically significant differences were found (P > 0.05).