Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models
Table 14
Urine parameters of rats treated with CHB-II-F for 4 weeks in the sub-chronic toxicity test.
Parameters
Dose (g/kg)
Control
26.20
13.10
6.55
Male
Color
Yellow
Yellow
Yellow
Yellow
Appearance
Clear
Clear
Clear
Clear
Leucocytes
-
-
-
-
Nitrite
-
-
-
-
Urobilinogen
Normal
Normal
Normal
Normal
Protein
-
-
-
-
pH
8.67±0.33
8.67±0.17
8.00±0.76
9.00±0.00
Occult blood
-
-
-
-
Specific gravity
1.03±0.00
1.03±0.00
1.03±0.00
1.03±0.00
Ketone body
-
-
-
-
Bilirubin
-
-
-
-
Glucose
-
-
-
-
Female
Color
Yellow
Yellow
Yellow
Yellow
Appearance
Clear
Clear
Clear
Clear
Leucocytes
-
-
-
-
Nitrite
-
-
-
-
Urobilinogen
Normal
Normal
Normal
Normal
Protein
-
-
-
-
pH
7.67±0.44
8.67±0.17
8.17±0.44
7.83±0.17
Occult blood
-
-
-
-
Specific gravity
1.02±0.00
1.03±0.00
1.03±0.00
1.03±0.00
Ketone body
-
-
-
-
Bilirubin
-
-
-
-
Glucose
-
-
-
-
Note: Data were presented as the mean ±SD from 12 rats. No statistically significant differences were found (P > 0.05). And “-” represents that no positive results need to be reported.
