Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models
Table 15
Urine parameters of rats treated with CHB-II-F after 2 weeks of recovery period in the sub-chronic toxicity test.
Parameters
Dose (g/kg)
Control
26.20
13.10
6.55
Male
Color
Yellow
Yellow
Yellow
Yellow
Appearance
Clear
Clear
Clear
Clear
Leucocytes
-
-
-
-
Nitrite
-
-
-
-
Urobilinogen
Normal
Normal
Normal
Normal
Protein
-
-
-
-
pH
7.72±0.02
8.03±0.70
8.01±0.65
7.31±0.11
Occult blood
-
-
-
-
Specific gravity
1.02±0.01
1.02±0.00
1.02±0.02
1.02±0.00
Ketone body
-
-
-
-
Bilirubin
-
-
-
-
Glucose
-
-
-
-
Female
Color
Yellow
Yellow
Yellow
Yellow
Appearance
Clear
Clear
Clear
Clear
Leucocytes
-
-
-
-
Nitrite
-
-
-
-
Urobilinogen
Normal
Normal
Normal
Normal
Protein
-
-
-
-
pH
7.03±0.12
7.36±0.13
7.26±0.31
7.53±0.07
Occult blood
-
-
-
-
Specific gravity
1.01±0.00
1.02±0.00
1.03±0.00
1.02±0.00
Ketone body
-
-
-
-
Bilirubin
-
-
-
-
Glucose
-
-
-
-
Note: Data were presented as the mean ±SD from 6 rats. No statistically significant differences were found (P > 0.05). And “-” represents that no positive results need to be reported.
