Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models

Table 9

ROW indices (g/g) of rats treated with CHB-II-F after 2 weeks of recovery period in the sub-chronic toxicity test.

Organ	Dose (g/kg)
	Control	26.20	13.10	6.55
Male
Brain	0.54±0.04	0.52±0.03	0.56±0.03	0.50±0.004
Heart	0.30±0.04	0.34±0.02	0.33±0.02	0.32±0.03
Liver	3.13±0.70	2.83±0.30	2.88±0.20	2.94±0.22
Spleen	0.23±0.05	0.19±0.06	0.21±0.06	0.20±0.03
Lung	0.61±0.15	0.62±0.12	0.55±0.24	0.54±0.19
Kidney	0.68±0.07	0.70±0.13	0.65±0.13	0.66±0.06
Thymus	0.12±0.02	0.13±0.01	0.11±0.04	0.11±0.04
Adrenal glands	0.02±0.01	0.03±0.01	0.02±0.02	0.02±0.00
Testes	0.96±0.12	0.92±0.11	1.03±0.12	0.93±0.09
Epididymis	0.30±0.09	0.29±0.06	0.35±0.04	0.33±0.05
bladder	0.04±0.01	0.03±0.01	0.04±0.01	0.03±0.00
Female
Brain	0.78±0.04	0.76±0.13	0.73±0.08	0.73±0.16
Heart	0.35±0.03	0.33±0.03	0.33±0.02	0.32±0.02
Liver	2.85±0.15	2.90±0.24	2.78±0.26	2.91±0.26
Spleen	0.23±0.05	0.23±0.05	0.21±0.04	0.23±0.03
Lung	0.75±0.09	0.62±0.60	0.69±0.07	0.76±0.23
Kidney	0.73±0.19	0.60±0.17	0.64±0.02	0.63±0.14
Thymus	0.13±0.02	0.14±0.04	0.15±0.03	0.15±0.03
Adrenal glands	0.04±0.04	0.04±0.04	0.04±0.05	0.02±0.01
Uterus	0.27±0.09	0.25±0.06	0.28±0.09	0.33±0.10
Ovary	0.06±0.01	0.06±0.01	0.05±0.02	0.07±0.01
bladder	0.04±0.13	0.04±0.01	0.04±0.01	0.04±0.05

Note: Data were presented as the mean ±SD from 6 rats. No statistically significant differences were found (P > 0.05).