Alpha7 nAChR Expression Is Correlated with Arthritis Development and Inhibited by Sinomenine in Adjuvant-Induced Arthritic Rats

Figure 1

Effects of SIN on clinical progression in AIA rats from day 0 to 30. Rats were treated with SIN, MTX, or PBS once daily for 30 days after CFA administration. (a) Hind paw volume, (b) AI, (c) ESR, and (d) serum TNF-α concentration were measured on days 0, 6, 12, 18, 24, and 30. Data are expressed as mean ± SD (n=8). P<0.05 versus the model group. (e) Clinical appearance of hind paws from the control or AIA rats treated with SIN, MTX, or PBS, on day 30 after CFA administration. (f) Marked lining layer hyperplasia in the synovium of the model group compared to the control, SIN, or MTX group in H&E stained sections (400×).

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