Research Article
Metabolomic Study on Nude Mice Models of Gastric Cancer Treated with Modified Si Jun Zi Tang via HILIC UHPLC-Q-TOF/MS Analysis
Table 4
Differential metabolites among groups in positive ion mode.
| Metabolites | m/z | RT(s) | HMDB | Normal vs. model | MSJZT vs. model | VIP | FC | P-value | VIP | FC | P-value |
| DHA | 346.2739 | 68.843 | HMDB0062579 | 6.248 | 0.660 | <0.001 | - | - | - | 7-Methylxanthine | 166.0523 | 74.755 | HMDB0001991 | 1.102 | 2.064 | 0.004 | - | - | - | 20-HETE | 338.2685 | 76.696 | HMDB0005998 | 4.895 | 0.134 | <0.001 | 3.945 | 0.530 | 0.001 | Nicotinamide | 123.0545 | 87.755 | HMDB0001406 | 2.055 | 0.691 | 0.018 | - | - | - | Uracil | 113.0336 | 142.0695 | HMDB0000300 | - | - | - | 2.409 | 0.541 | <0.001 | Thymine | 127.0492 | 165.724 | HMDB0000262 | 1.116 | 0.716 | 0.005 | - | - | - | Urea | 61.03878 | 172.386 | HMDB0000294 | 1.673 | 1.194 | 0.008 | - | - | - | Taurodeoxycholic acid | 517.3293 | 238.846 | HMDB0000896 | 1.234 | 3.026 | 0.013 | - | - | - | Triethanolamine | 150.1116 | 269.222 | HMDB0032538 | 1.030 | 0.296 | <0.001 | - | - | - | Nicotinamide N-oxide | 139.0494 | 273.546 | HMDB0002730 | 2.009 | 2.168 | <0.001 | 1.840 | 2.317 | <0.001 | L-Palmitoylcarnitine | 400.3417 | 293.014 | HMDB0000222 | 2.708 | 0.599 | 0.001 | 2.128 | 0.733 | 0.017 | Allantoin | 176.0772 | 328.55 | HMDB0000462 | - | - | - | 1.092 | 1.175 | 0.003 | LysoPC(18:0) | 524.3704 | 336.747 | HMDB0010384 | 14.905 | 0.682 | <0.001 | 3.465 | 0.857 | 0.032 | LysoPC(18:1(9Z)) | 522.3538 | 339.1875 | HMDB0002815 | 3.272 | 0.863 | 0.022 | - | - | - | LysoPC(16:0) | 496.339 | 382.673 | HMDB0010382 | 2.782 | 0.722 | 0.008 | - | - | - | Inosine | 269.0878 | 396.6175 | HMDB0000195 | - | - | - | 5.884 | 6.061 | 0.034 | Hypoxanthine | 137.045 | 396.832 | HMDB0000157 | - | - | - | 9.224 | 7.951 | 0.039 | 2-Hydroxyphenethylamine | 120.0798 | 469.973 | HMDB0001065 | 2.841 | 1.594 | 0.002 | 1.237 | 1.350 | 0.033 | L-Phenylalanine | 166.0857 | 469.984 | HMDB0000159 | 3.928 | 1.656 | 0.001 | 1.963 | 1.380 | 0.026 | L-Leucine | 132.1011 | 483.5645 | HMDB0000687 | 4.807 | 1.871 | 0.008 | - | - | - | Taurine | 126.0214 | 549.757 | HMDB0000251 | 2.156 | 0.774 | 0.007 | - | - | - | L-Tyrosine | 182.0804 | 555.5655 | HMDB0000158 | 1.041 | 1.509 | 0.008 | - | - | - | D-Pipecolic acid | 130.0853 | 573.452 | HMDB0005960 | 2.262 | 2.146 | 0.004 | - | - | - | Oxypurinol | 153.04 | 595.101 | HMDB0000786 | 1.085 | 0.079 | 0.031 | - | - | - | Xanthosine | 285.0826 | 595.101 | HMDB0000299 | 1.597 | 0.076 | 0.031 | - | - | - | L-Glutamine | 147.076 | 701.805 | HMDB0000641 | 4.637 | 1.378 | <0.001 | - | - | - | L-Pyroglutamic acid | 130.0493 | 701.8085 | HMDB0000267 | 3.973 | 1.249 | <0.001 | - | - | - | ACPC | 84.04351 | 702.062 | HMDB0036458 | 1.258 | 1.322 | <0.001 | - | - | - | Acetylcholine | 146.117 | 706.122 | HMDB0000895 | 1.773 | 0.696 | 0.027 | - | - | - | 1-Methylhistidine | 170.0919 | 722.94 | HMDB0000001 | 2.122 | 4.723 | 0.001 | 2.043 | 4.670 | <0.001 | Glycerophosphocholine | 258.1097 | 729.043 | HMDB0000086 | 8.256 | 0.619 | <0.001 | 8.243 | 0.847 | 0.006 | L-Citrulline | 176.1023 | 736.684 | HMDB0000904 | 1.982 | 1.356 | 0.001 | - | - | - | L-Glutamate | 148.0598 | 761.895 | HMDB0000148 | 1.559 | 0.564 | <0.001 | 1.872 | 0.740 | 0.018 | L-Histidine | 156.076 | 761.9205 | HMDB0000177 | 2.418 | 2.725 | 0.002 | 1.436 | 2.612 | 0.001 | Glycerol 3-phosphate | 173.0203 | 835.814 | HMDB0000126 | 1.290 | 0.212 | <0.001 | 1.238 | 0.551 | <0.001 |
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Notes: metabolites: potential biomarkers; RT: retention time; VIP: variable importance in the projection; FC: fold change; 20 HETE: 20-hydroxyeicosatetraenoic acid; ACPC: 1-aminocyclopropanecarboxylic acid.
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