Metabolomic Study on Nude Mice Models of Gastric Cancer Treated with Modified Si Jun Zi Tang via HILIC UHPLC-Q-TOF/MS Analysis

Table 4

Differential metabolites among groups in positive ion mode.

Metabolites	m/z	RT(s)	HMDB	Normal vs. model		MSJZT vs. model
				VIP	FC	P-value	VIP	FC	P-value
DHA	346.2739	68.843	HMDB0062579	6.248	0.660	<0.001	-	-	-
7-Methylxanthine	166.0523	74.755	HMDB0001991	1.102	2.064	0.004	-	-	-
20-HETE	338.2685	76.696	HMDB0005998	4.895	0.134	<0.001	3.945	0.530	0.001
Nicotinamide	123.0545	87.755	HMDB0001406	2.055	0.691	0.018	-	-	-
Uracil	113.0336	142.0695	HMDB0000300	-	-	-	2.409	0.541	<0.001
Thymine	127.0492	165.724	HMDB0000262	1.116	0.716	0.005	-	-	-
Urea	61.03878	172.386	HMDB0000294	1.673	1.194	0.008	-	-	-
Taurodeoxycholic acid	517.3293	238.846	HMDB0000896	1.234	3.026	0.013	-	-	-
Triethanolamine	150.1116	269.222	HMDB0032538	1.030	0.296	<0.001	-	-	-
Nicotinamide N-oxide	139.0494	273.546	HMDB0002730	2.009	2.168	<0.001	1.840	2.317	<0.001
L-Palmitoylcarnitine	400.3417	293.014	HMDB0000222	2.708	0.599	0.001	2.128	0.733	0.017
Allantoin	176.0772	328.55	HMDB0000462	-	-	-	1.092	1.175	0.003
LysoPC(18:0)	524.3704	336.747	HMDB0010384	14.905	0.682	<0.001	3.465	0.857	0.032
LysoPC(18:1(9Z))	522.3538	339.1875	HMDB0002815	3.272	0.863	0.022	-	-	-
LysoPC(16:0)	496.339	382.673	HMDB0010382	2.782	0.722	0.008	-	-	-
Inosine	269.0878	396.6175	HMDB0000195	-	-	-	5.884	6.061	0.034
Hypoxanthine	137.045	396.832	HMDB0000157	-	-	-	9.224	7.951	0.039
2-Hydroxyphenethylamine	120.0798	469.973	HMDB0001065	2.841	1.594	0.002	1.237	1.350	0.033
L-Phenylalanine	166.0857	469.984	HMDB0000159	3.928	1.656	0.001	1.963	1.380	0.026
L-Leucine	132.1011	483.5645	HMDB0000687	4.807	1.871	0.008	-	-	-
Taurine	126.0214	549.757	HMDB0000251	2.156	0.774	0.007	-	-	-
L-Tyrosine	182.0804	555.5655	HMDB0000158	1.041	1.509	0.008	-	-	-
D-Pipecolic acid	130.0853	573.452	HMDB0005960	2.262	2.146	0.004	-	-	-
Oxypurinol	153.04	595.101	HMDB0000786	1.085	0.079	0.031	-	-	-
Xanthosine	285.0826	595.101	HMDB0000299	1.597	0.076	0.031	-	-	-
L-Glutamine	147.076	701.805	HMDB0000641	4.637	1.378	<0.001	-	-	-
L-Pyroglutamic acid	130.0493	701.8085	HMDB0000267	3.973	1.249	<0.001	-	-	-
ACPC	84.04351	702.062	HMDB0036458	1.258	1.322	<0.001	-	-	-
Acetylcholine	146.117	706.122	HMDB0000895	1.773	0.696	0.027	-	-	-
1-Methylhistidine	170.0919	722.94	HMDB0000001	2.122	4.723	0.001	2.043	4.670	<0.001
Glycerophosphocholine	258.1097	729.043	HMDB0000086	8.256	0.619	<0.001	8.243	0.847	0.006
L-Citrulline	176.1023	736.684	HMDB0000904	1.982	1.356	0.001	-	-	-
L-Glutamate	148.0598	761.895	HMDB0000148	1.559	0.564	<0.001	1.872	0.740	0.018
L-Histidine	156.076	761.9205	HMDB0000177	2.418	2.725	0.002	1.436	2.612	0.001
Glycerol 3-phosphate	173.0203	835.814	HMDB0000126	1.290	0.212	<0.001	1.238	0.551	<0.001

Notes: metabolites: potential biomarkers; RT: retention time; VIP: variable importance in the projection; FC: fold change; 20 HETE: 20-hydroxyeicosatetraenoic acid; ACPC: 1-aminocyclopropanecarboxylic acid.