Metabolomic Study on Nude Mice Models of Gastric Cancer Treated with Modified Si Jun Zi Tang via HILIC UHPLC-Q-TOF/MS Analysis

Table 5

Differential metabolites among groups in negative ion mode.

Metabolites	m/z	RT(s)	HMDB	Normal vs. Model			MSJZT vs. model
				VIP	FC	P-value	VIP	FC	P-value
Acamprosate	180.0331	61.982	HMDB0014797	-	-	-	1.161	0.654	0.009
Acetylcarnitine	405.227	65.483	HMDB0000201	2.415	0.335	0.003	-	-	-
4-Pyridoxic acid	182.0455	67.1	HMDB0000017	1.601	0.478	<0.001	1.167	1.360	0.004
Arachidonic Acid	303.2328	68.26	HMDB0060102	6.673	0.861	0.005	-	-	-
Stearic acid	567.5289	70.053	HMDB0000827	1.329	1.677	0.024	-	-	-
Linoleic acid	279.233	71.276	HMDB0000673	16.236	0.816	0.002	-	-	-
Palmitic acid	511.4722	72.976	HMDB0000220	2.605	0.885	0.048	-	-	-
Myristic acid	227.2015	74.892	HMDB0000806	7.495	1.401	0.001	8.339	1.240	0.014
Dodecanoic acid	199.1701	76.7325	HMDB0000638	-	-	-	2.971	1.169	0.032
3-Hydroxycapric acid	187.1335	78.2555	HMDB0002203	-	-	-	1.522	1.361	0.023
Uracil	111.0198	143.866	HMDB0000300	5.091	0.507	<0.001	-	-	-
L-Gulonic gamma-lactone	177.0403	189.902	HMDB0003466	5.649	2.119	0.001	-	-	-
2′-Deoxyuridine	227.0674	198.477	HMDB0000012	1.969	0.736	0.008	-	-	-
Taurochenodeoxycholate	498.2884	222.406	HMDB0000951	2.638	5.607	<0.001	-	-	-
Indolelactic acid	204.0664	257.5135	HMDB0000671	1.019	0.502	<0.001	-	-	-
Allantoin	157.0364	329.079	HMDB0000462	-	-	-	3.841	1.332	<0.001
Phenylacetylglycine	192.0665	365.929	HMDB0000821	-	-	-	1.494	1.877	0.007
Hippuric acid	178.0507	375.18	HMDB0000714	-	-	-	1.181	0.541	0.018
Inosine	267.0734	399.819	HMDB0000195	-	-	-	6.101	11.093	0.034
D-Quinovose	223.0822	423.6645	NA	-	-	-	1.141	3.170	0.010
DL-lactate	89.02428	445.111	HMDB0000755	10.283	0.699	<0.001	1.765	0.787	0.037
Pseudouridine	243.0619	451.015	HMDB0000767	1.293	1.381	0.006	2.082	1.419	0.002
L-Tryptophan	203.0826	470.464	HMDB0000929	2.132	1.405	0.028	-	-	-
L-Phenylalanine	164.0716	471.676	HMDB0000159	3.089	1.835	0.002	3.308	1.439	0.016
L-Isoleucine	130.0873	485.879	HMDB0000172	4.704	2.277	0.015	-	-	-
Taurine	124.0072	553.905	HMDB0000251	1.629	0.798	0.026	-	-	-
D-Allose	239.0772	563.703	HMDB0001151	4.919	2.221	<0.001	-	-	-
Alpha-D-Glucose	179.0563	564.292	HMDB0003345	6.480	1.791	0.001	-	-	-
D-Ribose	149.0452	579.172	HMDB0000283	1.404	2.149	<0.001	1.246	2.388	0.016
Xanthosine	283.0684	597.003	HMDB0000299	1.830	0.081	0.030	-	-	-
2-Oxoadipic acid	141.0169	628.85	HMDB0000225	7.548	1.062	0.001	-	-	-
L-Glutamine	145.0619	703.715	HMDB0000641	4.210	1.699	<0.001	4.608	1.404	0.002
Dihydrothymine	127.0509	703.732	HMDB0000079	1.113	1.667	<0.001	-	-	-
Phosphorylcholine	242.0798	731.901	HMDB0001565	1.185	0.584	<0.001	1.163	0.803	0.005
L-Citrulline	174.0884	738.368	HMDB0000904	1.288	1.536	0.002	-	-	-
Glycerol 3-phosphate	171.0062	836.0675	HMDB0000126	1.183	0.620	0.003	1.253	0.214	<0.001

Notes: metabolites: potential biomarkers; RT: retention time; VIP: variable importance in the projection; FC: fold change; P-value: calculated by Student’s t-tests.