Design, Preparation, and Characterization of Dioscin Nanosuspensions and Evaluation of Their Protective Effect against Carbon Tetrachloride-Induced Acute Liver Injury in Mice
Table 4
Screening of stabilizers.
Type
Content
MPS
PDI
Macrostability of the system
F-68
0.5%
145.17
0.227
The suspension is white and opaque, producing flocculent precipitates and deepening the color of the system.
SDS
0.5%
125.47
0.196
The suspension is white and opaque and easy to precipitate. It can be dispersed into an original emulsion.
PVP K30
0.5%
91
0.301
The suspension is white and opaque, and it produces microprecipitates, which can be dispersed into an original emulsion.
Tween-80
0.5%
108.8
0.316
The suspension is white and opaque. It is easy to precipitate. It cannot be dispersed into an original emulsion.
Soybean lecithin
0.5%
201
0.269
The suspension is white and opaque, and it produces microprecipitates, which can be dispersed into an original emulsion.
Sodium cholate
0.5%
89.43
0.298
The suspension is white and opaque. It is easy to precipitate. It cannot be dispersed into an original emulsion.
F-68 + SDS
0.25% + 0.25%
175.23
0.294
The suspension is white and opaque, and it produces microprecipitates, which can be dispersed into an original emulsion.
PVP K30 + SDS
0.25% + 0.25%
128.57
0.265
The suspension is white and opaque, and it produces microprecipitates, which can be dispersed into an original emulsion.
Tween + SDS
0.25% + 0.25%
160.5
0.530
The suspension is white and opaque, producing flocculent precipitates and deepening the color of the system.
Lecithin + SDS
0.25% + 0.25%
99.84
0.228
The suspension is white and opaque, and it produces microprecipitates, which can be dispersed into an original emulsion.
F-68 + PVP K30
0.25% + 0.25%
124.2
0.247
The suspension is white and opaque, and it produces microprecipitates, which can be dispersed into an original emulsion.
