Design, Preparation, and Characterization of Dioscin Nanosuspensions and Evaluation of Their Protective Effect against Carbon Tetrachloride-Induced Acute Liver Injury in Mice

Table 6

Response value of the formulation using a central composite design (n = 3).

Run	A	B	C	MPS	PDI	OD
1	0	0	0	97.98	0.250	0.661
2	+1	−1	+1	131.45	0.203	0.39
3	0	0	0	97.98	0.250	0.661
4	0	0	0	97.99	0.250	0.661
5	+1	+1	+1	104.9	0.267	0.55
6	−1	−1	−1	85.49	0.226	0.841
7	0	+1.68	0	96.9	0.25	0.67
8	−1	−1	+1	90.29	0.235	0.772
9	−1	+1	+1	106.4	0.27	0.53
10	+1	−1	−1	102.4	0.261	0.59
11	0	0	+1.68	98.23	0.253	0.65
12	0	0	0	97.98	0.250	0.661
13	0	0	0	97.98	0.250	0.661
14	+1.68	0	0	141.6	0.345	0
15	+1	+1	−1	92.93	0.24	0.74
16	−1.68	0	0	108.24	0.274	0.5
17	0	−1.68	0	91.56	0.239	0.75
18	0	0	0	98.97	0.250	0.661
19	0	0	−1.68	74.88	0.238	0.868
20	−1	+1	−1	101.57	0.263	0.59