Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway
The expression of JAK2 mRNA in the pancreas. (a) In the SO, SAP, R, S, and DCQD groups, differences between 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significant (). (b) At 3 hours, 6 hours, 12 hours, and 18 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different (). (c) At the same timepoints, differences between the SAP group versus the S group are not significant (). DCQD, Da-Cheng-Qi decoction; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; JAK2, Janus kinase 2; mRNA, messenger ribonucleic acid; p-JAK2, phosphorylated Janus kinase 2; p-STAT3, phosphorylated signal transducers and transcription 3; R, ruxolitinib-treated rats with severe acute pancreatitis; S, Stattic-treated rats with severe acute pancreatitis; SAP, severe acute pancreatitis; SO, sham operation; STAT3, signal transducers and transcription 3.
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