Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway

Table 1

Comparisons of the dynamic serum amylase levels.

Group	3 hours	6 hours	12 hours	18 hours
SO	1589.5 ± 179.3	2910.5 ± 725.4^★	1600.5 ± 252.7^★	1637.1 ± 277.7
SAP	6329.7 ± 1496.3^♀	9951.0 ± 1825.7^▲♂	8523.9 ± 1359.9^▲☆	6784.0 ± 795.6^▲◎
R	3871.0 ± 1112.5^♀	4689.4 ± 1059.3^■♂	5390.6 ± 1009.1^■☆	4754.9 ± 1197.8^■◎
S	4114.5 ± 979.4^♀	5579.6 ± 956.9^•♂	6129.7 ± 1227.4^•☆	5157.2 ± 1127.8^•◎
DCQD	3219.5 ± 895.7^♀	4272.8 ± 930.1^◢♂	4917.5 ± 990.6^◢☆	4037.8 ± 833.9^◢◎

Note: The data are presented as U/L. ^★In the SO group, 3 hours versus 6 hours and 6 hours versus 12 hours are significantly different (). ^▲In the SAP group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^■In the R group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^•In the S group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^◢In the DCQD group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^♀At 3 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^♂At 6 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^☆At 12 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^◎At 18 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. DCQD, Da-Cheng-Qi decoction; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL-4, interleukin 4; IL-6, interleukin 6; IL-10 interleukin 10; JAK2, Janus kinase 2; p-JAK2, phosphorylated Janus kinase 2; p-STAT3, phosphorylated signal transducers and transcription 3; R, ruxolitinib-treated rats with severe acute pancreatitis; S, Stattic-treated rats with severe acute pancreatitis; SAP, severe acute pancreatitis; SO, sham operation; STAT3, signal transducers and transcription 3; TNF-α, tumor necrosis factor alpha.