Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway

Table 2

Comparisons of the dynamic TNF-α levels.

Group	3 hours	6 hours	12 hours	18 hours
SO	12.45 ± 3.32	18.01 ± 4.97^★	15.29 ± 5.11^★	13.93 ± 6.87
SAP	89.87 ± 16.37^♀	148.56 ± 17.97^▲♂	187.58 ± 20.09^▲☆	163.22 ± 25.16^▲◎
R	63.70 ± 19.65^♀	98.94 ± 20.97^■♂	147.25 ± 27.85^■☆	124.85 ± 24.93^■◎
S	71.21 ± 20.17^♀	119.77 ± 23.39^•♂	156.25 ± 23.17^•☆	135.78 ± 26.67^•◎
DCQD	53.85 ± 18.32^♀	89.38 ± 20.47^◢♂	131.87 ± 22.41^◢☆	110.54 ± 25.01^◢◎

Note: The data are presented as pg/mL. ^★In the SO group, 3 hours versus 6 hours and 6 hours versus 12 hours are significantly different (). ^▲In the SAP group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^■In the R group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^•In the S group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different ().^◢In the DCQD group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^♀ At 3 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^♂At 6 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^☆ At 12 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^◎ At 18 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. DCQD, Da-Cheng-Qi decoction; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL-4, interleukin 4; IL-6, interleukin 6; IL-10 interleukin 10; JAK2, Janus kinase 2; p-JAK2, phosphorylated Janus kinase 2; p-STAT3, phosphorylated signal transducers and transcription 3; R, ruxolitinib-treated rats with severe acute pancreatitis; S, Stattic-treated rats with severe acute pancreatitis; SAP, severe acute pancreatitis; SO, sham operation; STAT3, signal transducers and transcription 3; TNF-α, tumor necrosis factor alpha.