Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 6

Research Article

Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway

Table 6

Comparisons of the protein expression of p-JAK2 in the pancreas.

Group3 hours6 hours12 hours18 hours

SO0.412 ± 0.0750.487 ± 0.1120.556 ± 0.1220.454 ± 0.107
SAP0.733 ± 0.186♀a0.980 ± 0.199▲♂a1.223 ± 0.223▲☆a0.935 ± 0.197▲◎a
R0.622 ± 0.1120.881 ± 0.181■♂1.110 ± 0.207■☆0.855 ± 0.184■◎
S0.715 ± 0.190♀a0.980 ± 0.192•♂a1.231 ± 0.214•☆a0.941 ± 0.189•◎a
DCQD0.683 ± 0.1140.871 ± 0.187◢♂1.101 ± 0.211◢☆0.871 ± 0.193◢◎

Note: The data are presented as the p-JAK2/GAPDH ratio. In the SO group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the SAP group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the R group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the S group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different ().In the DCQD group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). At 3 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 6 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 12 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 18 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. aAt the same timepoints, the SAP group versus the S group was not significantly different (). DCQD, Da-Cheng-Qi decoction; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL-4, interleukin 4; IL-6, interleukin 6; IL-10 interleukin 10; JAK2, Janus kinase 2; p-JAK2, phosphorylated Janus kinase 2; p-STAT3, phosphorylated signal transducers and transcription 3; R, ruxolitinib-treated rats with severe acute pancreatitis; S, Stattic-treated rats with severe acute pancreatitis; SAP, severe acute pancreatitis; SO, sham operation; STAT3, signal transducers and transcription 3; TNF-α, tumor necrosis factor alpha.

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