Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway

Table 6

Comparisons of the protein expression of p-JAK2 in the pancreas.

Group	3 hours	6 hours	12 hours	18 hours
SO	0.412 ± 0.075	0.487 ± 0.112^★	0.556 ± 0.122^★	0.454 ± 0.107^★
SAP	0.733 ± 0.186^♀a	0.980 ± 0.199^▲♂a	1.223 ± 0.223^▲☆a	0.935 ± 0.197^▲◎a
R	0.622 ± 0.112^♀	0.881 ± 0.181^■♂	1.110 ± 0.207^■☆	0.855 ± 0.184^■◎
S	0.715 ± 0.190^♀a	0.980 ± 0.192^•♂a	1.231 ± 0.214^•☆a	0.941 ± 0.189^•◎a
DCQD	0.683 ± 0.114^♀	0.871 ± 0.187^◢♂	1.101 ± 0.211^◢☆	0.871 ± 0.193^◢◎

Note: The data are presented as the p-JAK2/GAPDH ratio. ^★In the SO group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^▲In the SAP group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^■In the R group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^•In the S group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different ().^◢In the DCQD group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^♀At 3 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^♂At 6 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^☆At 12 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^◎At 18 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^aAt the same timepoints, the SAP group versus the S group was not significantly different (). DCQD, Da-Cheng-Qi decoction; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL-4, interleukin 4; IL-6, interleukin 6; IL-10 interleukin 10; JAK2, Janus kinase 2; p-JAK2, phosphorylated Janus kinase 2; p-STAT3, phosphorylated signal transducers and transcription 3; R, ruxolitinib-treated rats with severe acute pancreatitis; S, Stattic-treated rats with severe acute pancreatitis; SAP, severe acute pancreatitis; SO, sham operation; STAT3, signal transducers and transcription 3; TNF-α, tumor necrosis factor alpha.