Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway

Table 9

Comparison of the protein expression of p-STAT3 in the terminal ileum.

Group	3 hours	6 hours	12 hours	18 hours
SO	0.342 ± 0.065	0.403 ± 0.067^★	0.443 ± 0.074^★	0.364 ± 0.057^★
SAP	0.691 ± 0.144^♀	0.912 ± 0.175^▲♂	1.291 ± 0.214^▲☆	0.890 ± 0.168^▲◎
R	0.645 ± 0.120^♀	0.813 ± 0.124^■♂	0.984 ± 0.187^■☆	0.780 ± 0.170^■◎
S	0.577 ± 0.110^♀	0.710 ± 0.123^•♂	0.861 ± 0.165^•☆	0.700 ± 0.162^•◎
DCQD	0.557 ± 0.107^♀	0.673 ± 0.129^◢♂	0.808 ± 0.175^◢☆	0.679 ± 0.167^◢◎

Note: The data are presented as the p-STAT3/GAPDH ratio. ^★In the SO group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^▲In the SAP group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^■In the R group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^•In the S group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^◢In the DCQD group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^♀At 3 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^♂At 6 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^☆At 12 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^◎At 18 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. DCQD, Da-Cheng-Qi decoction; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL-4, interleukin 4; IL-6, interleukin 6; IL-10 interleukin 10; JAK2, Janus kinase 2; p-JAK2, phosphorylated Janus kinase 2; p-STAT3, phosphorylated signal transducers and transcription 3; R, ruxolitinib-treated rats with severe acute pancreatitis; S, Stattic-treated rats with severe acute pancreatitis; SAP, severe acute pancreatitis; SO, sham operation; STAT3, signal transducers and transcription 3; TNF-α, tumor necrosis factor alpha.