Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 9

Research Article

Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway

Table 9

Comparison of the protein expression of p-STAT3 in the terminal ileum.

Group3 hours6 hours12 hours18 hours

SO0.342 ± 0.0650.403 ± 0.0670.443 ± 0.0740.364 ± 0.057
SAP0.691 ± 0.1440.912 ± 0.175▲♂1.291 ± 0.214▲☆0.890 ± 0.168▲◎
R0.645 ± 0.1200.813 ± 0.124■♂0.984 ± 0.187■☆0.780 ± 0.170■◎
S0.577 ± 0.1100.710 ± 0.123•♂0.861 ± 0.165•☆0.700 ± 0.162•◎
DCQD0.557 ± 0.1070.673 ± 0.129◢♂0.808 ± 0.175◢☆0.679 ± 0.167◢◎

Note: The data are presented as the p-STAT3/GAPDH ratio. In the SO group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the SAP group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the R group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the S group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the DCQD group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). At 3 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 6 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 12 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 18 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. DCQD, Da-Cheng-Qi decoction; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL-4, interleukin 4; IL-6, interleukin 6; IL-10 interleukin 10; JAK2, Janus kinase 2; p-JAK2, phosphorylated Janus kinase 2; p-STAT3, phosphorylated signal transducers and transcription 3; R, ruxolitinib-treated rats with severe acute pancreatitis; S, Stattic-treated rats with severe acute pancreatitis; SAP, severe acute pancreatitis; SO, sham operation; STAT3, signal transducers and transcription 3; TNF-α, tumor necrosis factor alpha.

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